Phosgene → Cyclopentyl chloroformate

HRID 1079036Notes

Reaction equation

HRID 1079036 reaction equation
[CH:1]1([OH:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7](Cl)([Cl:9])=[O:8]>C(Cl)Cl.C1(C)C=CC=CC=1>[Cl:9][C:7]([O:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:8]

Participants

5

Reactant 2

HCID 6371PhosgeneHCID 7298Cyclopentanol

Product 1

HCID 2735892Cyclopentyl chloroformate

Reagents, catalysts & solvents 2

HCID 1140TolueneSolvent2×HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 0.543 g of cyclopentyl alcohol in 15 ml of methylene chloride is added to a 0° C. solution of 1.0 ml of a 10% toluene solution of phosgene in toluene in 10 ml of methylene chloride. The reaction is allowed to warm to room temperature and is stirred for 3 hours. The reaction is concentrated at reduced pressure, diluted with 15 ml of toluene and reconcentrated to dryness to give the product.

Workup

  1. concentrationThe reaction is concentrated at reduced pressure
  2. additiondiluted with 15 ml of toluene
  3. customto give the product

Sources & evidence

ORD record
ord-c1d0e99bc6874afea7239da56800c2fa
Source dataset
uspto-grants-1996_08
Patent number
US05550257

Reaction notes

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