Clofibric Acid → HCID 15839971, compound

HRID 1079459Notes

Reaction equation

[CH3:1][C:2]([O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)([CH3:6])[C:3]([OH:5])=O.[N+]([O-])(O)=O.[O:19]([CH2:23][CH2:24][NH2:25])[N+:20]([O-:22])=[O:21].C(OC(C)C)(C)C>>[O:19]([CH2:23][CH2:24][NH:25][C:3](=[O:5])[C:2]([CH3:1])([O:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[CH3:6])[N+:20]([O-:22])=[O:21]

Participants

Reactant 3

HCID 2797Clofibric Acid

HCID 7914Diisopropyl Ether

HCID 78397Ethanol, 2-amino-, 1-nitrate, nitrate (1:1)

Product 1

HCID 15839971HCID 15839971, compoundYield 19.6%

Procedure

Following a similar treatment to that in Example 2 and using 0.91 g of 2-methyl-2-(4-chlorophenoxy)propionic acid and 0.60 g of nitroxyethylamine nitrate, 0.21 g of the title compound was obtained as colorless needles (solvent for recrystallization; diisopropyl ether).

Sources & evidence

ORD record: ord-dd7ffd1951d64dadbcf786ad474b8aed
Source dataset: uspto-grants-1996_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05580893

Reaction notes

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