反应详情

温度

75 °C

A mixture of 3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (4.3 g, 18 mmol), K2CO3 (5.5 g, 40 mmol), and 1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone (5.5 g, 18 mmol), and dimethylforrnamide (6t3 ml) was stirred and heated at 75° C. for 16 hours. The reaction was poured into water and was extracted with ethyl acetate. The ethyl acetate was washed (water), dried (MgSO4), and the solvent concentrated to afford 7.2 g of a beige solid. Recrystallization (twice) from ethyl alcohol yielded 3.3 g (43%) of 1-[4-[4-[4-(1,2-benzisoxazol-3-yl)-1-piperidinyl]bitoxyl]-3-methoxyphenyl]ethanone, m.p.=99°-101° C.

1. extractionwas extracted with ethyl acetate
2. washThe ethyl acetate was washed (water)
3. dry with materialdried (MgSO4)
4. concentrationthe solvent concentrated