Thiazole → 3-(2-Hydroxyethyl)-1,3-thiazol-3-ium bromide

HRID 1080180Notes

Reaction equation

HRID 1080180 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[Br:6][CH2:7][CH2:8][OH:9]>>[Br-:6].[OH:9][CH2:8][CH2:7][N+:3]1[CH:4]=[CH:5][S:1][CH:2]=1

Participants

3

Reactant 2

HCID 9256ThiazoleHCID 108982-Bromoethanol

Product 1

HCID 138881473-(2-Hydroxyethyl)-1,3-thiazol-3-ium bromide

Procedure

Thiazole (4.3 g) and 2-bromoethanol (12.5 g) were mixed and heated under reflux for 5 hours. The reaction was left standing at room temperature to give white needles. The crystals were washed with acetone, collected by filtration and dried under reduced pressure.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 5 hours
  3. waitThe reaction was left
  4. customstanding at room temperature
  5. customto give white needles
  6. washThe crystals were washed with acetone
  7. filtrationcollected by filtration
  8. customdried under reduced pressure

Sources & evidence

ORD record
ord-6d8ff83a71c74d93878a9c194cdb7a9b
Source dataset
uspto-grants-1996_12
Patent number
US05580904

Reaction notes

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