2-Bromoethanol → HCID 23367168, compound

HRID 1080182Notes

Reaction equation

HRID 1080182 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.[O:7]1CCO[CH2:9][CH2:8]1.[Br:13]CCO>CC(C)=O>[Br-:13].[OH:7][CH2:8][CH2:9][N+:3]1[C:2]([CH3:1])=[CH:6][S:5][CH:4]=1

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 127484-MethylthiazoleHCID 312751,4-Dioxane

Product 1

HCID 23367168HCID 23367168, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To the mixture of 4-methylthiazole (24 g) and dioxane (30 ml) was added 2-bromoethanol (40 g), and the resulting mixture was heated under reflux for 4 hours. To the reaction left standing at room temperature for about 0.5 hour was added acetone (100 ml) with stirring to give white to pale yellow solids, which were collected by filtration, washed with acetone and dried under reduced pressure.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 4 hours
  3. waitTo the reaction left
  4. customto give white to pale yellow solids, which
  5. filtrationwere collected by filtration
  6. washwashed with acetone
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-437b78572e0f4ef1a9342976ec1aa2c0
Source dataset
uspto-grants-1996_12
Patent number
US05580904

Reaction notes

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