Ethanol → HCID 67757980, compound

HRID 1080185Notes

Reaction equation

HRID 1080185 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][OH:9].[ClH:10].[CH3:11][N:12]([CH2:14][CH2:15][Cl:16])[CH3:13].C(O)C>CC(C)=O>[ClH:16].[Cl-:10].[CH3:11][N:12]([CH3:13])[CH2:14][CH2:15][N+:3]1[C:2]([CH3:1])=[C:6]([CH2:7][CH2:8][OH:9])[S:5][CH:4]=1

Participants

5

Reactant 3

HCID 702Ethanol2×HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

Product 1

HCID 67757980HCID 67757980, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a mixture of 4-methyl-5-thiazole ethanol (16.0 g) and dimethylaminoethyl chloride hydrochloride (14.4 g) was added ethanol (10 ml. The mixture was heated under reflux for about 20 hours. Ethanol (10 ml) and acetone (100 ml) were added, and the mixture was stirred to give pale yellow powdery crystals, which were collected by filtration, washed with acetone containing a small amount of ethanol and dried under reduced pressure.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for about 20 hours
  3. customto give pale yellow powdery crystals, which
  4. filtrationwere collected by filtration
  5. washwashed with acetone containing a small amount of ethanol
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-8b4427ce23a844aaa4be4503851aa221
Source dataset
uspto-grants-1996_12
Patent number
US05580904

Reaction notes

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