反应详情

A 25 ml THF solution of 1.0M 4-(4-(3,4-difluorophenyl)phenyl)cyclohexyl magnesium bromide (25 mmol) was dripped into a mixed solution of 5.36 g (20.0 mmol) of 4-iodo-1-n-propyl-1-silacyclohexane, 50 mg of copper (I) iodide, 100 mg of triethyl phosphite and 50 ml of THF. The silacyclohexane rings of the product thus obtained were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 1.49 g (yield 36%) of the target product, i.e. the trans, trans isomers. The obtained target product exhibited the same physical properties as the product of Example 1.

1. customThe silacyclohexane rings of the product thus obtained
2. additiona mixture of trans isomers and cis isomers
3. customAfter a conventional after treatment, they were separated by means of chromatography