反应详情

A mixture of 5.67 g of 2,6-dichloropurine, 6.89 g of 1,2,3,4-tetrahydroisoquinoline hydrochloride and 6 g of triethylamine in 40 ml of dimethylacetamide was stirred under a nitrogen atmosphere at room temperature for 3.5 hours. The mixture was poured into 500 ml of water and stirred for 30 minutes. The solids were filtered, washed with water, pressed dry and stirred in hot methanol for 1 hour. The suspension was filtered while hot and the solids dried, 9.85 g (95% yield), m.p. 271°-276° C. dec.

1. stirringstirred for 30 minutes
2. filtrationThe solids were filtered
3. washwashed with water
4. custompressed dry
5. stirringstirred in hot methanol for 1 hour
6. filtrationThe suspension was filtered while hot and the solids
7. customdried