Triethylamine → HCID 23365519, compound

HRID 1080675Notes

Reaction equation

HRID 1080675 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.Cl.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:33]=[CH:34][C:35]=1[O:36][CH3:37])[CH2:18][CH:19]1[C:28]2[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=2)[CH2:22][CH2:21][NH:20]1.[CH2:38](N(CC)CC)C>C(Cl)Cl>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH3:38])=[C:4]([N:20]2[CH2:21][CH2:22][C:23]3[C:28](=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=3)[CH:19]2[CH2:18][C:17]2[CH:33]=[CH:34][C:35]([O:36][CH3:37])=[C:15]([O:14][CH3:13])[CH:16]=2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 53244122,6-DichloropurineHCID 16667431Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)

Product 1

HCID 23365519HCID 23365519, compoundYield 45.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the procedure of Preparation D, 2.01 g of 2,6-dichloropurine, 3.76 g of 1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride and 4 g of triethylamine in 20 ml of methylene chloride gave 2.31 g of the titled product.

Sources & evidence

ORD record
ord-f7e99b1b7d6b45849827a944a6f57594
Source dataset
uspto-grants-1996_12
Patent number
US05583137

Reaction notes

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