反应详情

温度

80 °C

4,7-Dimethyl-1H-indole-2,3-dione (700 mg) in dry DMF (10 ml) was cooled to 0° C. and sodium hydride (80% dispersion in mineral oil, 120 mg) was added. After 30 minutes at 0° C. 1-(2-chloroethyl)-4-(phenylmethyl)piperazine (1 g) in dry DMF (5 ml) was added. The mixture was heated to 80° C. for 2 hours and then evaporated under reduced pressure. The residue was subjected to flash chromatography and then treated with ethanolic HCl to give 4,7-dimethyl-1-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-1H-indole-2,3-dione dihydrochloride, m.p. 223°-227° C. (dec.).

1. customevaporated under reduced pressure
2. additiontreated with ethanolic HCl