Tetrahydrofuran → HCID 86750071, compound

HRID 1081322Notes

Reaction equation

HRID 1081322 reaction equation
[F:1][C:2]([F:40])([F:39])[C:3]1[CH:4]=[C:5]([CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=1)[CH2:6][N:7]([CH3:31])[C:8]([C:10]1[N:19]([CH3:20])[C:18](=[O:21])[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[C:11]=1[C:22]1[CH:27]=[CH:26][C:25]([C:28]([OH:30])=[O:29])=[CH:24][CH:23]=1)=[O:9].[CH2:41]1COCC1.[N+](=C)=[N-]>C(OCC)C>[F:38][C:35]([F:36])([F:37])[C:33]1[CH:32]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:39])[F:40])[CH:34]=1)[CH2:6][N:7]([CH3:31])[C:8]([C:10]1[N:19]([CH3:20])[C:18](=[O:21])[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[C:11]=1[C:22]1[CH:27]=[CH:26][C:25]([C:28]([O:30][CH3:41])=[O:29])=[CH:24][CH:23]=1)=[O:9]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 9550DiazomethaneHCID 86750072HCID 86750072, compound

Product 1

HCID 86750071HCID 86750071, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a mixture of the compound obtained in Example 74 (50 mg) and THF (15 ml) was added a solution of diazomethane (excess) in ethyl ether. After the mixture was stirred for 30 minutes at room temperature, the solvent was evaporated to give the titled compound as colorless crystals (25 mg).

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-47c3b232cac14468a9735fdba68dd7df
Source dataset
uspto-grants-1996_12
Patent number
US05585385

Reaction notes

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