Hydrochloric Acid → HCID 23364115, compound

HRID 1081325Notes

Reaction equation

HRID 1081325 reaction equation
C([O:3][C:4]([C:6]1[N:15]([CH3:16])[C:14](=[O:17])[C:9]2=[N:10][CH:11]=[CH:12][N:13]=[C:8]2[C:7]=1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)=[O:5])C.[OH-].[Na+].Cl.[Na+].[Cl-]>C1COCC1.C(O)C>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[CH:12][N:13]=3)[C:14](=[O:17])[N:15]([CH3:16])[C:6]=2[C:4]([OH:5])=[O:3])=[CH:19][CH:20]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 53733479HCID 53733479, compound

Product 1

HCID 23364115HCID 23364115, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the compound (1.10 g) obtained in Step 3, ethanol (25 ml), THF (25 ml) and 1N-NaOH (13 ml) was stirred for one hour under reflux. The reaction mixture was cooled, to which was added dilute HCl to adjust the pH to 3-4. The mixture was saturated with NaCl, followed by extraction with ethyl acetate. The extract solution was dried, then the solvent was distilled off to leave the above-titled compound as colorless crystals (0.93 g).

Workup

  1. temperatureunder reflux
  2. temperatureThe reaction mixture was cooled, to which
  3. extractionfollowed by extraction with ethyl acetate
  4. customThe extract solution was dried
  5. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-2c86ec9454294395b5f7f635f5e69bb0
Source dataset
uspto-grants-1996_12
Patent number
US05585385

Reaction notes

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