Piperidine → Piperidine-1-sulfonyl chloride

HRID 1081342Notes

Reaction equation

HRID 1081342 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([S:1]([Cl:5])(=[O:3])=[O:2])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 24648Sulfuryl chloride

Product 1

HCID 11298344Piperidine-1-sulfonyl chloride

Procedure

A solution of 4 g of sulfuryl chloride in acetronitrile was treated dropwise with 861 mg of piperidine at ambient temperature under an atmosphere of nitrogen. After complete addition, the mixture was refluxed for 18 h, cooled to room temperature and concentrated in vacuo to yield the title product as a red oil. TLC: Rf=0.86, CH2Cl2. (1H)-NMR (CDCl3) consistent with structure.

Workup

  1. additionAfter complete addition
  2. temperaturethe mixture was refluxed for 18 h
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8c899d8117df4bb1941b0a238fa9cbe2
Source dataset
uspto-grants-1996_12
Patent number
US05585397

Reaction notes

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