Piperidine → HCID 15231557, compound

HRID 1081490Notes

Reaction equation

HRID 1081490 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:7]([O:9][C:10]1[CH:46]=[CH:45][C:13]2[N:14]([S:24]([C:27]3[CH:32]=[CH:31][C:30]([NH:33][C:34](OC4C=CC=CC=4)=[O:35])=[CH:29][C:28]=3[O:43][CH3:44])(=[O:26])=[O:25])[C:15](=[O:23])[N:16]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:12]=2[CH:11]=1)[CH3:8]>C(Cl)Cl>[CH2:7]([O:9][C:10]1[CH:46]=[CH:45][C:13]2[N:14]([S:24]([C:27]3[CH:32]=[CH:31][C:30]([NH:33][C:34]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:35])=[CH:29][C:28]=3[O:43][CH3:44])(=[O:25])=[O:26])[C:15](=[O:23])[N:16]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)[C:12]=2[CH:11]=1)[CH3:8]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 15231555HCID 15231555, compound

Product 1

HCID 15231557HCID 15231557, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2 ml of piperidine were added to a solution of 500 mg of the compound obtained in Example 16 step A) in 25 ml of DCM. The reaction mixture was then stirred for 18 hours at room temperature. It was concentrated to dryness and the resulting product was passed over silica using DCM and then a DCM/AcOEt mixture (95/5; v/v) as the eluent to give 0.36 g of the expected product in the form of white crystals. M.p. =232° C.

Workup

  1. concentrationIt was concentrated to dryness

Sources & evidence

ORD record
ord-fbfccd8cc4434e60afd0f08c2fd9c224
Source dataset
uspto-grants-1996_12
Patent number
US05585394

Reaction notes

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