Ammonium formate → HCID 23362662, compound

HRID 1081533Notes

Reaction equation

HRID 1081533 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][O:7][CH2:6][CH:5]([CH2:9][NH2:10])[N:4]1CC1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:1][CH2:2][CH:3]1[CH2:8][O:7][CH2:6][CH:5]([CH2:9][NH2:10])[NH:4]1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 23362648HCID 23362648, compound

Product 1

HCID 23362662HCID 23362662, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

3,5-Bis-aminomethyl-4-benzylmorpholine (1.3 g, 5.5 mmol) was dissolved in methanol (50 ml). Ammonium-formiate (1.4 g, 22 mmol) and palladium on activated carbon (10%, 5 g) were added. The reaction mixture was stirred at 50° C. under nitrogen for 3 hours. The catalyst was then filtered off and washed with several small portions of methanol and the solution evaporated to dryness. The tri-amine was used direcly in the next reaction step. FAB/MS: 146 (M+1).

Workup

  1. filtrationThe catalyst was then filtered off
  2. washwashed with several small portions of methanol
  3. customthe solution evaporated to dryness
  4. customThe tri-amine was used direcly in the next reaction step

Sources & evidence

ORD record
ord-bcfecd86464746d1b78fd19e860ccc40
Source dataset
uspto-grants-1996_12
Patent number
US05587144

Reaction notes

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