反应详情

To the mixture of 10 g of 4-methoxybenzamidine hydrochloride, 7.7 g of ethyl acetoacetate and 16.3 g of potassium carbonate were added 120 ml of ethanol, and the mixture was heat-refluxed with stirring for 7 hours. The reaction mixture was cooled and filtered to remove insoluble substances. The filtrate was evaporated. Water was added to the residue to dissolve and then the resulting solution was neutralized with acetic acid. The precipitated crystals were filtered off, washed with water and dried. Whereby 10.9 g of the desired substance was obtained as white crystals. Melting point is 202° to 203° C.

1. temperaturethe mixture was heat-refluxed
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customto remove insoluble substances
5. customThe filtrate was evaporated
6. additionWater was added to the residue
7. dissolutionto dissolve
8. filtrationThe precipitated crystals were filtered off
9. washwashed with water
10. customdried
11. customWhereby 10.9 g of the desired substance was obtained as white crystals