2-Acetyl-5-bromothiophene → HCID 178466101, compound

HRID 1082791Notes

Reaction equation

HRID 1082791 reaction equation
CC(=O)c1ccc(Br)s1.CC(C)c1nccn1C>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+].c1ccc(-c2nn(-c3ccccc3)c(-c3ccccc3)c2-n2nccc2P(C2CCCCC2)C2CCCCC2)cc1>CC(=O)c1ccc(-c2cnc(C(C)C)n2C)s1

Participants

8

Reactant 2

HCID 793352-Acetyl-5-bromothiopheneHCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazole

Product 1

HCID 178466101HCID 178466101, compoundYield 90.82%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 534309145-(Dicyclohexylphosphino)-1',3',5'-triphenyl-[1,4']-bi-1H-pyrazoleCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-8ace3961b2984ca5a9d22d730e4f6711
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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