2-Bromobiphenyl → HCID 178481277, 화합물

HRID 1082919노트

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HRID 1082919 반응식
Brc1ccccc1-c1ccccc1.Cn1cnc(C#N)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CCCCC1(P(C2CCCCC2)C2CCCCC2)c2ccccc2-c2ccccc21.[K+]>Cn1cnc(C#N)c1-c1ccccc1-c1ccccc1

참가 물질

8

반응물 2

HCID 163292-BromobiphenylHCID 27951151-Methyl-1H-imidazole-4-carbonitrile

생성물 1

HCID 178481277HCID 178481277, 화합물수율 0.62%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 71310598(9-Butylfluoren-9-yl)-dicyclohexylphosphane촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

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온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-ffc229866ee24de68499e4c29296fb30
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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