1-Methylimidazole → HCID 178481235, compound

HRID 1083033Notes

Reaction equation

HRID 1083033 reaction equation
CC(C)(C)NS(=O)(=O)c1cncc(Br)c1.Cn1ccnc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC12CC3(C)OC(C)(CC(C)(O1)P3c1ccccc1)O2.[K+]>Cn1cncc1-c1cncc(S(=O)(=O)NC(C)(C)C)c1

Participants

8

Reactant 2

HCID 13901-MethylimidazoleHCID 617949515-Bromo-N-tert-butylpyridine-3-sulfonamide

Product 1

HCID 178481235HCID 178481235, compoundYield 19.29%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 534277901,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-ae17eb2de0954ba79b5dcf1dc98e6dbc
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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