1-Bromo-2-fluorobenzene → HCID 178440020, compound

HRID 1083216Notes

Reaction equation

HRID 1083216 reaction equation
CC(C)c1nccn1C.Fc1ccccc1Br>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].FC(F)(F)c1cc(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1.[K+]>CC(C)c1ncc(-c2ccccc2F)n1C

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazole

Product 1

HCID 178440020HCID 178440020, compoundYield 72.71%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 2778032Tris[3,5-bis(trifluoromethyl)phenyl]phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-dd52002e788b44e5b08fa6cc9d0053f2
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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