3-Bromo-5-(trifluoromethyl)pyridine → HCID 178440021, compound

HRID 1083265Notes

Reaction equation

HRID 1083265 reaction equation
CC(C)c1nccn1C.FC(F)(F)c1cncc(Br)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+].c1coc(P(c2ccco2)c2ccco2)c1>CC(C)c1ncc(-c2cncc(C(F)(F)F)c2)n1C

Participants

8

Reactant 2

HCID 111279913-Bromo-5-(trifluoromethyl)pyridineHCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazole

Product 1

HCID 178440021HCID 178440021, compoundYield 98.01%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 521585Tris(furan-2-yl)phosphaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-4c83832c2ef643889700dfffa0ae57b0
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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