1-Methylimidazole → HCID 129873665, compound

HRID 1083484Notes

Reaction equation

HRID 1083484 reaction equation
CC(=O)c1ccc(Br)s1.Cn1ccnc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC(C)(C)P(c1ccccc1)C(C)(C)C.[K+]>CC(=O)c1ccc(-c2cncn2C)s1

Participants

8

Reactant 2

HCID 13901-MethylimidazoleHCID 793352-Acetyl-5-bromothiophene

Product 1

HCID 129873665HCID 129873665, compoundYield 87.71%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 316378Di-tert-butylphenylphosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-1fb297a2224c41cc9f5585be3cf0e3bc
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

Loading…