1-Bromo-2-fluorobenzene → HCID 178526665, compound

HRID 1083551Notes

Reaction equation

HRID 1083551 reaction equation
Fc1ccccc1Br.O=[N+]([O-])c1ccc(-n2ccnc2-c2ccccc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].COc1ccc(OC)c(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.[K+]>O=[N+]([O-])c1ccc(-n2c(-c3ccccc3F)cnc2-c2ccccc2)cc1

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 11173122HCID 11173122, compound

Product 1

HCID 178526665HCID 178526665, compoundYield 60.12%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 44597232Bis(3,5-bis(trifluoromethyl)phenyl)(3,6-dimethoxy-2',4',6'-tri(propan-2-yl)(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-87be56eeb79444ebbb328781d43f5da8
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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