Benzofuran, 5-bromo- → HCID 178510009, compound

HRID 1083621Notes

Reaction equation

HRID 1083621 reaction equation
Brc1ccc2occc2c1.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].COc1ccccc1P(c1ccccc1OC)c1ccccc1OC.[K+]>N#Cc1ccc(-n2cncc2-c2ccc3occc3c2)cc1

Participants

8

Reactant 2

HCID 90015Benzofuran, 5-bromo-HCID 135744Benzonitrile, p-imidazol-1-yl-

Product 1

HCID 178510009HCID 178510009, compoundYield 21.56%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 78464Tris(o-methoxyphenyl)phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-ba6fa3c6ee3a4ee6944ae7f4ce5bdf05
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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