1-Bromo-2-fluorobenzene → HCID 178510011, compound

HRID 1083677Notes

Reaction equation

HRID 1083677 reaction equation
Fc1ccccc1Br.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CN(C)c1cccc(N(C)C)c1-c1ccccc1P(c1ccccc1)C(C)(C)C.[K+]>N#Cc1ccc(-n2cncc2-c2ccccc2F)cc1

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 135744Benzonitrile, p-imidazol-1-yl-

Product 1

HCID 178510011HCID 178510011, compoundYield 12.24%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 1212377832'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-63a5e293fdf94165be31bed0cb8b513e
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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