Benzonitrile, p-imidazol-1-yl- → HCID 178468654, compound

HRID 1083718Notes

Reaction equation

HRID 1083718 reaction equation
CCOC(=O)c1cc(Br)cn1CC.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CCP(CC)c1ccccc1-n1c2ccccc2c2ccccc21.[K+]>CCOC(=O)c1cc(-c2cncn2-c2ccc(C#N)cc2)cn1CC

Participants

8

Reactant 2

HCID 135744Benzonitrile, p-imidazol-1-yl-HCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 178468654HCID 178468654, compoundYield 7.18%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 1188786229-[2-(Diethylphosphino)phenyl]-9H-carbazoleCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-5e02cc20afb64541a86ebdd85235fe92
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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