Benzonitrile, p-imidazol-1-yl- → HCID 178468654, 화합물

HRID 1083730노트

반응식

HRID 1083730 반응식
CCOC(=O)c1cc(Br)cn1CC.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+].c1ccc(P(c2ccccc2)c2ccccc2)cc1>CCOC(=O)c1cc(-c2cncn2-c2ccc(C#N)cc2)cn1CC

참가 물질

8

반응물 2

HCID 135744Benzonitrile, p-imidazol-1-yl-HCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 178468654HCID 178468654, 화합물수율 6.37%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 11776Triphenylphosphine촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

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온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-f7b78d8518704afb8fcc5d2d520f30b4
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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