1-Bromo-2-fluorobenzene → HCID 178505607, compound

HRID 1083895Notes

Reaction equation

HRID 1083895 reaction equation
FC(F)n1ccnc1-c1ccccc1.Fc1ccccc1Br>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+].c1ccc(-c2nn(-c3ccccc3)c(-c3ccccc3)c2-n2nccc2P(C2CCCCC2)C2CCCCC2)cc1>Fc1ccccc1-c1cnc(-c2ccccc2)n1C(F)F

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 534857661-(Difluoromethyl)-2-phenyl-1H-imidazole

Product 1

HCID 178505607HCID 178505607, compoundYield 92.43%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 534309145-(Dicyclohexylphosphino)-1',3',5'-triphenyl-[1,4']-bi-1H-pyrazoleCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-1107e8a6134c4b23a1317e6653eb7988
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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