1-Methylimidazole → HCID 73057931, compound

HRID 1083953Notes

Reaction equation

HRID 1083953 reaction equation
Cn1ccnc1.Fc1ccccc1Br>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.[K+]>Cn1cncc1-c1ccccc1F

Participants

8

Reactant 2

HCID 13901-MethylimidazoleHCID 612591-Bromo-2-fluorobenzene

Product 1

HCID 73057931HCID 73057931, compoundYield 41.01%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 27342172-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenylCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-9b93a9ded1434f06aa7d8cdcbccb0012
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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