1-Bromo-2-fluorobenzene → HCID 178456432, compound

HRID 1083984Notes

Reaction equation

HRID 1083984 reaction equation
CC(C)n1ccnc1.Fc1ccccc1Br>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].FC(F)(F)c1cc(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1.[K+]>CC(C)n1cncc1-c1ccccc1F

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 101761131H-Imidazole, 1-(1-methylethyl)-

Product 1

HCID 178456432HCID 178456432, compoundYield 10.23%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 2778032Tris[3,5-bis(trifluoromethyl)phenyl]phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-53a08654b3a94050b8bd3a5692afdfd4
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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