1-Bromo-2-fluorobenzene → HCID 178456432, compound

HRID 1083993Notes

Reaction equation

HRID 1083993 reaction equation
CC(C)n1ccnc1.Fc1ccccc1Br>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC12CC3(C)OC(C)(CC(C)(O1)P3c1ccccc1)O2.[K+]>CC(C)n1cncc1-c1ccccc1F

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 101761131H-Imidazole, 1-(1-methylethyl)-

Product 1

HCID 178456432HCID 178456432, compoundYield 9.42%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 534277901,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-3020af94914b4a268f04c8e98e59495f
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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