Benzofuran, 5-bromo- → HCID 178481276, 화합물

HRID 1084105노트

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HRID 1084105 반응식
Brc1ccc2occc2c1.Cn1cnc(C#N)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].[K+].c1coc(P(c2ccco2)c2ccco2)c1>Cn1cnc(C#N)c1-c1ccc2occc2c1

참가 물질

8

반응물 2

HCID 90015Benzofuran, 5-bromo-HCID 27951151-Methyl-1H-imidazole-4-carbonitrile

생성물 1

HCID 178481276HCID 178481276, 화합물수율 40.68%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 521585Tris(furan-2-yl)phosphane촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

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온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-370fec365a48438ab2f8945cfc771ffd
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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