HCID 11173122, compound → HCID 178468650, compound

HRID 1084185Notes

Reaction equation

HRID 1084185 reaction equation
CCOC(=O)c1cc(Br)cn1CC.O=[N+]([O-])c1ccc(-n2ccnc2-c2ccccc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC12CC3(C)OC(C)(CC(C)(O1)P3c1ccccc1)O2.[K+]>CCOC(=O)c1cc(-c2cnc(-c3ccccc3)n2-c2ccc([N+](=O)[O-])cc2)cn1CC

Participants

8

Reactant 2

HCID 11173122HCID 11173122, compoundHCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 178468650HCID 178468650, compoundYield 32.12%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 534277901,3,5,7-Tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-c24be4a41f5d48778c795560e5b82e8b
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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