反应详情

温度

80 °C

27.8 g (0.3 mol) of chloroacetone, 16.0 g (0.1 mol) of 3-chloro-α,α-dimethylbenzylamine and 11.2 g (0.11 mol) of triethylamine were dissolved in 200 ml of N,N-dimethylacetamide, and the mixture was heated at 80° C.. for 3 hours under stirring. The reaction solution was cooled, then poured into a large amount of water and extracted with toluene. The toluene layer was washed with water and then dried over anhydrous magensium sulfate. Then, the toluene layer was distilled off under reduced pressure to obtain 6.9 g (yield: 30.6%) of the desired compound.

1. temperatureThe reaction solution was cooled
2. extractionextracted with toluene
3. washThe toluene layer was washed with water
4. dry with materialdried over anhydrous magensium sulfate
5. distillationThen, the toluene layer was distilled off under reduced pressure