Hydrochloric Acid → HCID 20062527, compound

HRID 1084708Notes

Reaction equation

HRID 1084708 reaction equation
[CH2:1]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)[C:2]#[CH:3].[CH2:20]=O.[CH:22]1([CH2:28][NH:29][CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][NH:32]2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.Cl>>[CH:22]1([CH2:28][NH:29][CH2:30][CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][N:32]2[CH2:20][C:3]#[C:2][CH2:1][N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 145520855,11-dihydro-11-(2-propynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 20062518HCID 20062518, compound

Product 1

HCID 20062527HCID 20062527, compoundYield 34%

Procedure

Prepared analogously to Example lb) from 5,11-dihydro-11-(prop-2-ynyl)-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, paraformaldehyde and 2-[[(cyclohexyl)methylamino]methyl]piperidine in a yield of 34% of theory. The monohydrochloride melted at 205° C. (decomp.).

Sources & evidence

ORD record
ord-4656e4ef49df4ef5ac01b4343ff5bf35
Source dataset
uspto-grants-1991_04
Patent number
US05006522

Reaction notes

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