5,11-Dihydro-11-[4-(1-piperidinyl)-but-2-ynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 5,11-Dihydro-11-[4-(1-piperidinyl)butyl]-6H-pyrido[2,3-b][l,4]benzodiazepin-6-one

HRID 1084710Notes

Reaction equation

HRID 1084710 reaction equation
[N:1]1([CH2:7][C:8]#[C:9][CH2:10][N:11]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[C:15](=[O:22])[NH:14][C:13]3[CH:23]=[CH:24][CH:25]=[N:26][C:12]2=3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(OCC)(=O)C>[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[C:15](=[O:22])[NH:14][C:13]3[CH:23]=[CH:24][CH:25]=[N:26][C:12]2=3)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 145520905,11-Dihydro-11-[4-(1-piperidinyl)-but-2-ynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 145521015,11-Dihydro-11-[4-(1-piperidinyl)butyl]-6H-pyrido[2,3-b][l,4]benzodiazepin-6-oneYield 35%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogously to Example 8 from 5,11-dihydro-11-[4-(1-piperidinyl)-but-2-ynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one in a yield of 35% of theory. Colourless crystals, m.p. 131°-132° C. (ethyl acetate).

Sources & evidence

ORD record
ord-ca07fb1ce11140b19bd4b6c1c1513129
Source dataset
uspto-grants-1991_04
Patent number
US05006522

Reaction notes

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