Diethyl 3-tert.butyl-2-isoxazolin-5-ylphosphonate → (3-tert-Butyl-4,5-dihydro-1,2-oxazol-5-yl)phosphonic acid

HRID 1084801Notes

Reaction equation

HRID 1084801 reaction equation
[C:1]([C:5]1[CH2:9][CH:8]([P:10](=[O:17])([O:14]CC)[O:11]CC)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2]>Br.C(O)(=O)C>[C:1]([C:5]1[CH2:9][CH:8]([P:10](=[O:11])([OH:17])[OH:14])[O:7][N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 86744708Diethyl 3-tert.butyl-2-isoxazolin-5-ylphosphonate

Product 1

HCID 3079426(3-tert-Butyl-4,5-dihydro-1,2-oxazol-5-yl)phosphonic acid

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

39.6 g (0.15 mol) of the compound from Example 26 are dissolved in a mixture of 100 ml of 33% strength HBr/glacial acetic acid solution and 50 ml of glacial acetic acid.

Sources & evidence

ORD record
ord-f24c5b647cdf46038b1a56e6c3513a51
Source dataset
uspto-grants-1991_04
Patent number
US05006515

Reaction notes

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