反应详情

0.57 ml (9.2 mmol) of methyl iodide and, at -50° C., 327 mg (10.9 mmol) of 80% strength sodium hydride are added under a nitrogen atmosphere to 3 g (8.4 mmol) of the compound from Example 4 in 100 ml of dry tetrahydrofuran. The mixture is stirred for 2 hours and the temperature is allowed to rise to 25° C. in the course of this. Water is cautiously added to the mixture and it is extracted several times using ether, and the organic phase is dried over sodium sulphate and concentrated in vacuo.

1. customto rise to 25° C. in the course
2. extractionis extracted several times
3. dry with materialthe organic phase is dried over sodium sulphate
4. concentrationconcentrated in vacuo