3-Hydroxybenzaldehyde → HCID 14293612, compound

HRID 1085042Notes

Reaction equation

HRID 1085042 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH:10]#[N:11]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C@H:5]([OH:6])[C:10]#[N:11]

Participants

3

Reactant 2

HCID 1013-HydroxybenzaldehydeHCID 768Hydrogen Cyanide

Product 1

HCID 14293612HCID 14293612, compound

Procedure

61 mg (0.5 mmol) of meta-hydroxybenzaldehyde were reacted at pH 3.25 with 450 μl of 4.2M aqueous HCN solution in accordance with Example 14. The reaction was complete after 30 to 40 minutes. The (S)-3-hydroxymandelonitrile was isolated as described in Example 14.

Sources & evidence

ORD record
ord-669bf67256ec40238007bcefd4289d72
Source dataset
uspto-grants-1991_04
Patent number
US05008192

Reaction notes

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