Hydrogen Cyanide → HCID 12717592, compound
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH:10]#[N:11]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C@H:5]([OH:6])[C:10]#[N:11]Participants
3
Procedure
60 mg (0.5 mmol) of meta-methylbenzaldehyde were reacted at pH 3.25 with 475 μl of 4.2M aqueous HCN solution and 500 μl of oxynitrilase solution in accordance with Example 14. The reaction was complete after about 45 minutes. The work-up was carried out analogously to Example 1 to give (S)-3-methylmandelonitrile.
Sources & evidence
- ORD record
- ord-c5fb6127d52c4409987e81437a384843
- Source dataset
- uspto-grants-1991_04
- Patent number
- US05008192
Reaction notes
Loading…