Isopropanol → HCID 20061368, compound

HRID 1085252Notes

Reaction equation

C(O)(C)C.[CH3:5][N:6]1[C:11]([N:12]([CH3:17])[CH2:13][CH2:14][NH:15][CH3:16])=[CH:10][C:9](=[O:18])C(C)[C:7]1=[O:20].[N+:21]([C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][CH2:32]Br)=[CH:26][CH:25]=1)([O-:23])=[O:22].[CH2:34]([N:36](CC)CC)C>>[CH3:5][N:6]1[C:11]([N:12]([CH2:13][CH2:14][N:15]([CH2:32][CH2:31][CH2:30][C:27]2[CH:28]=[CH:29][C:24]([N+:21]([O-:23])=[O:22])=[CH:25][CH:26]=2)[CH3:16])[CH3:17])=[CH:10][C:9](=[O:18])[N:36]([CH3:34])[C:7]1=[O:20]

Participants

Reactant 4

HCID 3776Isopropanol

HCID 8471Triethylamine

HCID 104444821-(3-Bromopropyl)-4-nitrobenzene

HCID 20061302HCID 20061302, compound

Product 1

HCID 20061368HCID 20061368, compound

Procedure

To 60 ml of isopropanol were added 5.0 g of the above compound 18, 5.5 g of 3-(4-nitrophenyl)propyl bromide and 6 ml of triethylamine, and the resuting mixture was then treated by the same procedure as in Example 2 in order to obtain 8.1 g of 1,3-dimethyl-6-{N-methyl-2-[N-methyl-3-(4-nitrophenyl)propylamino]ethylamino}-2,4(1H,3H)-pyrimidinedione.

Workup

additionthe resuting mixture was then treated by the same procedure as in Example 2 in order

Sources & evidence

ORD record: ord-ccc11fc741e841e98813d6d1f63e49be
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05008267

Reaction notes

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