Ethanolamine → HCID 20061116, compound

HRID 1085295Notes

Reaction equation

HRID 1085295 reaction equation
Cl[C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12].[CH2:13]([CH2:15][NH2:16])[OH:14].C(N(CC)CC)C>C(O)(C)C>[OH:14][CH2:13][CH2:15][NH:16][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH3:12]

Participants

5

Reactant 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 132969876-Chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 20061116HCID 20061116, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

6-chloro-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione (3.4 g) was suspended in 30 ml of isopropanol, and the suspension was added with 1.26 ml of ethanolamine and 3.8 ml of triethylamine and then the resultant mixture was refluxed for 3 hours. The reaction mixture was allowed to stand overnight at room temperature, and thereafter crystals formed were collected by filtration, washed with water and then recrystallized using a water-ethanol solution (1:1, v/v), thereby 2.9 g of 6-(2-hydroxyethylamino)-1,3,5-trimethyl-2,4(1H,3H)-pyrimidinedione being obtained.

Workup

  1. customcrystals formed
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customrecrystallized

Sources & evidence

ORD record
ord-2186b3e1ff814175b7218f41cd376278
Source dataset
uspto-grants-1991_04
Patent number
US05008267

Reaction notes

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