Triethylamine → HCID 15056302, compound

HRID 1085414Notes

Reaction equation

HRID 1085414 reaction equation
[O:1]=[C:2]([N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)[CH:3]=[CH2:4].[Cl:18][C:19]1[CH:24]=[C:23]([SH:25])[CH:22]=[C:21]([Cl:26])[C:20]=1[OH:27].C(N(CC)CC)C>CO>[Cl:18][C:19]1[CH:24]=[C:23]([S:25][CH2:4][CH2:3][C:2]([N:5]2[CH2:6][CH2:7][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:9][CH2:10]2)=[O:1])[CH:22]=[C:21]([Cl:26])[C:20]=1[OH:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 30163632,6-Dichloro-4-mercaptophenolHCID 15056293HCID 15056293, compound

Product 1

HCID 15056302HCID 15056302, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(1-Oxo-2-propenyl)-4-(phenylmethyl)piperazine (2.53 g, 0.011 mole) and 2,6-dichloro-4-mercaptophenol (2.15 g, 0.011 mole) were dissolved in methanol (75 ml). Triethylamine (1 ml) was added and the reaction stirred for 12 hours. The solvent was removed, and the product purified by chromatography on silica, eluting with ethyl acetate/hexane.

Workup

  1. customThe solvent was removed
  2. customthe product purified by chromatography on silica
  3. washeluting with ethyl acetate/hexane

Sources & evidence

ORD record
ord-7945b37c026243a9bdf025f4cf1f6c65
Source dataset
uspto-grants-1991_04
Patent number
US05010080

Reaction notes

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