Hydrazine hydrate (1:1) → HCID 20060099, compound

HRID 1085465Notes

Reaction equation

HRID 1085465 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH:9]2[CH2:11][CH2:10]2)[N:3]=1.O.[NH2:13][NH2:14]>C(O)C>[NH:13]([C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH:9]2[CH2:11][CH2:10]2)[N:3]=1)[NH2:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19804698HCID 19804698, compound

Product 1

HCID 20060099HCID 20060099, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.0 g of 2-chloro-4-methyl-6-cyclopropylpyrimidine are dissolved in 30 ml of ethanol; 3.8 ml of hydrazine hydrate are added and the mixture is stirred for 20 hours at room temperature. The solvent is then evaporated off in vacuo and the residue is recrystallised with ethyl acetate. M.p. 98°-99° C.

Workup

  1. customThe solvent is then evaporated off in vacuo
  2. customthe residue is recrystallised with ethyl acetate

Sources & evidence

ORD record
ord-80d05987f4c04b3f87a30da479f6ac04
Source dataset
uspto-grants-1991_04
Patent number
US05010082

Reaction notes

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