反应详情

To 25 ml of N,N-dimethylformamide were added 12 g of diiodoethane and 8.3 g of potassium carbonate, a solution of 6.07 g of the compound obtained in Example 4 dissolved in 60 ml of N,N-dimethylformamide was gradually dropped thereinto, and the mixture was stirred for 30 minutes at the same temperature. N,N-Dimethylformamide was evaporated therefrom in vacuo, the residue was dissolved in a mixture of chloroform and methanol (2:1), washed with water, dried over magnesium sulfate, the solvent was evaporated therefrom, and the crystals separated out therefrom were washed with ether to give 3.35 g of ethyl 6,7,8-trifluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate.

1. additionwas gradually dropped
2. customN,N-Dimethylformamide was evaporated
3. dissolutionin vacuo, the residue was dissolved in a mixture of chloroform and methanol (2:1)
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. customthe solvent was evaporated
7. customthe crystals separated
8. washout therefrom were washed with ether