Hydrochloric Acid → HCID 19768592, compound

HRID 1085844Notes

Reaction equation

HRID 1085844 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([C:13]([NH:15][CH2:16][CH2:17][NH:18]C(=O)OC(C)(C)C)=[O:14])=[N:3]1.FC(F)(F)C(O)=O.[ClH:33]>>[ClH:33].[NH2:18][CH2:17][CH2:16][NH:15][C:13]([C:4]1[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:6][N:2]([CH3:1])[N:3]=1)=[O:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 54153779HCID 54153779, compound

Product 1

HCID 19768592HCID 19768592, compoundYield 90.4%

Procedure

In an analoqous manner to that described in Examples 16 and 17, from 4.6 g (13.4 mmol) of t-butyl [2-(1-methyl-4-phenyl-3-pyrazolecarboxamido)ethyl]carbamate there were obtained, after cleavage of the t-butoxycarbonyl group with trifluoroacetic acid and working-up, 4.8 g of the crude hydrochloride. Recrystallization from ethanol/diethyl ether yielded 3.4 g (90%) of N-(2-aminoethyl)-1-methyl-4-phenyl-3-pyrazolecarboxamide hydrochloride as white crystals, melting point 182°.

Workup

  1. customthere were obtained
  2. customRecrystallization from ethanol/diethyl ether

Sources & evidence

ORD record
ord-aec7016686fb4ca3a2b00c9144270395
Source dataset
uspto-grants-1991_04
Patent number
US05011849

Reaction notes

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