Isopropanol → HCID 14717227, compound

HRID 1085883Notes

Reaction equation

HRID 1085883 reaction equation
[K].[NH2:2][C:3]1[N:8]=[C:7]([F:9])[CH:6]=[C:5](F)[N:4]=1.[CH:11]([OH:14])([CH3:13])[CH3:12]>>[NH2:2][C:3]1[N:8]=[C:7]([F:9])[CH:6]=[C:5]([O:14][CH:11]([CH3:13])[CH3:12])[N:4]=1

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 12014802-Amino-4,6-difluoropyrimidineHCID 5462222Potassium

Product 1

HCID 14717227HCID 14717227, compound

Procedure

29.4 g (0.3 mol) of potassium isopropylate were reacted as in 1.2 with 39.3 g (0.3 mol) of 2-amino-4,6-difluoropyrimidine (A.1a) in a total of 400 ml of isopropanol. After the working up, washing with petroleum ether and water in the usual manner, 38.5 g (75% of theory) of the title compound of melting point 66°-68° C. were obtained.

Workup

  1. washAfter the working up, washing with petroleum ether and water in the usual manner, 38.5 g (75% of theory) of the title compound of melting point 66°-68° C.
  2. customwere obtained

Sources & evidence

ORD record
ord-660f9e644dab46dba9c48fe78b04d4d0
Source dataset
uspto-grants-1991_04
Patent number
US05011927

Reaction notes

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