Acetic Acid → HCID 72273890, compound

HRID 1085922Notes

Reaction equation

HRID 1085922 reaction equation
[CH2:1]([CH:8]=[CH:9]CCCCC)[C:2]1C=CC=C[CH:3]=1.CCOCC.[C:20]([OH:23])(=[O:22])[CH3:21].O>C1COCC1>[C:20]([OH:23])([OH:22])=[CH:21][CH2:3][CH2:2][CH2:1][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 77374747HCID 77374747, compound

Product 1

HCID 72273890HCID 72273890, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the benzyl ether 4, 80 ml of acetic acid and 20 ml of water in 50 ml of THF was stirred at 70° C. overnight. The solution was then concentrated under vacuum and the residue purified by chromatography over silica gel (3 EtOAc: 2 hexanes) to provide the title compound.

Workup

  1. concentrationThe solution was then concentrated under vacuum
  2. customthe residue purified by chromatography over silica gel (3 EtOAc: 2 hexanes)

Sources & evidence

ORD record
ord-eabf241e26a14d6cae9824d7d817e58d
Source dataset
uspto-grants-1991_04
Patent number
US05011943

Reaction notes

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