Diethylamine → HCID 178476537, compound

HRID 1086129Notes

Reaction equation

HRID 1086129 reaction equation
C(NCC)C.[NH:6](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:7]([C:15]([N:17]1[CH2:61][CH2:60][CH2:59][C@H:18]1[C:19]([NH:21][C@H:22]([C:30]([NH:32][C@H:33]([C:41]([NH:43][C@H:44]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:40])[NH2:39])=[O:31])[CH2:23][S:24][S:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:20])=[O:16])[CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:14])[NH2:13]>CN(C)C=O>[NH2:6][C@H:7]([C:15]([N:17]1[CH2:61][CH2:60][CH2:59][C@H:18]1[C:19]([NH:21][C@H:22]([C:30]([NH:32][C@H:33]([C:41]([NH:43][C@H:44]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:39])[NH2:40])=[O:31])[CH2:23][S:24][S:25][C:26]([CH3:29])([CH3:27])[CH3:28])=[O:20])=[O:16])[CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:13])[NH2:14].[CH3:44][C:52]([OH:54])=[O:53].[CH3:44][C:52]([OH:54])=[O:53].[CH3:44][C:52]([OH:54])=[O:53]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 178451185HCID 178451185, compound

Product 1

HCID 178476537HCID 178476537, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.32 ml of diethylamine are added to a solution of 3.3 g of Fmoc-Arg-Pro-Cys(StBu)-Arg-Phe-OtBu (crude substance) in 20 ml of dimethylformamide. After 10 minutes at room temperature, the mixture is concentrated in vacuo. The residue is triturated with ether and filtered off with suction.

Workup

  1. concentrationthe mixture is concentrated in vacuo
  2. customThe residue is triturated with ether
  3. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-8c79338c4f4544e787cbb3e0b9ab8140
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

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