Styrene Oxide → HCID 53821622, compound

HRID 1086150Notes

Reaction equation

HRID 1086150 reaction equation
[Br:1][C:2]1[S:3][C:4]([Br:10])=[CH:5][C:6]=1[CH2:7][CH2:8][NH2:9].[CH2:11]1[O:19][CH:12]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(#N)C>[OH:19][CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:11][NH:9][CH2:8][CH2:7][C:6]1[CH:5]=[C:4]([Br:10])[S:3][C:2]=1[Br:1]

Participants

4

Reactant 2

HCID 7276Styrene OxideHCID 19826901HCID 19826901, compound

Product 1

HCID 53821622HCID 53821622, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2,5-dibromothiophene-3-ethylamine (31.6 g) and styrene oxide (13.3 g) in acetonitrile (135 ml) was heated under reflux for 24 hours. After standing at room temperature, brown crystals were filtered contaminated by traces of black tar. Recyrstallisation from acetonitrile (45 ml) with carbon treatment gave the title product (m.p. 94°) as tan crystals.

Workup

  1. temperatureunder reflux for 24 hours
  2. customAfter standing at room temperature
  3. filtrationbrown crystals were filtered

Sources & evidence

ORD record
ord-b82aebf604094ef6b9f7fdc63b622b83
Source dataset
uspto-grants-1991_07
Patent number
US05028602

Reaction notes

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